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The causal effect of obesity on prediabetes and insulin resistance reveals the important role of adipose tissue in insulin resistance

14 Sept 2020

Abstract excerpt

Reverse causality has made it difficult to establish the causal directions between obesity and prediabetes and obesity and insulin resistance. To disentangle whether obesity causally drives prediabetes and insulin resistance already in non-diabetic individuals, we utilized the UK Biobank and METSIM cohort to perform a Mendelian randomization (MR) analyses in the non-diabetic individuals. Our results suggest that...

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Share to Adipokines, Inflammation, and Metabolic Diseases
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PMID: 32925908
DOI: 10.1371/journal.pgen.1009018

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