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Article

Causal associations between insulin and Lp(a) levels in Caucasian population: a Mendelian randomization study.

Cardiovascular diabetology - 29 Aug 2024

Lejawa Mateusz, Goławski Marcin, Fronczek Martyna, Osadnik Tadeusz, Paneni Francesco, Ruscica Massimiliano, Pawlas Natalia, Lisik Małgorzata, Banach Maciej

Abstract excerpt

BACKGROUND: Numerous observational studies have demonstrated that circulating lipoprotein(a) [Lp(a)] might be inversely related to the risk of type 2 diabetes (T2D). However, recent Mendelian randomization (MR) studies do not consistently support this association. The results of in vitro research suggest that high insulin concentrations can suppress Lp(a) levels by affecting apolipoprotein(a) [apo(a)] synthesis....

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Identifiers

PMID: 39210428
DOI: 10.1186/s12933-024-02389-7
PMCID: PMC11360791

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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