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Sex-specific Mendelian randomization study of genetically predicted insulin and cardiovascular events in the UK Biobank

5 Sept 2019

Abstract excerpt

Insulin drives growth and reproduction which trade-off against longevity. Genetically predicted insulin, i.e., insulin proxied by genetic variants, is positively associated with ischemic heart disease, but sex differences are unclear, despite different disease rates and reproductive strategies by sex. We used Mendelian randomization in 392,010 white British from the UK Biobank to assess the sex-specific role of...

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Share to Cardiovascular Function and Risk Factors
Share to Diabetes, Cardiovascular Risks, and Lipoproteins
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PMID: 31508506
DOI: 10.1038/s42003-019-0579-z

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