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Article

Body Fat Distribution, Fasting Insulin Levels, and Insulin Secretion: A Bidirectional Mendelian Randomization Study.

The Journal of clinical endocrinology and metabolism - 17 May 2023

Gagnon Eloi, Mitchell Patricia L, Arsenault Benoit J

Abstract excerpt

CONTEXT: Hyperinsulinemia and adiposity are associated with one another, but the directionality of this relation is debated. OBJECTIVE: Here, we tested the direction of the causal effects of fasting insulin (FI) levels and body fat accumulation/distribution using 2-sample bidirectional Mendelian randomization (MR). METHODS: We included summary statistics from large-scale genome-wide association studies for body...

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Identifiers

PMID: 36585897
DOI: 10.1210/clinem/dgac758

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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