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Article

Overall and central obesity with insulin sensitivity and secretion in a Han Chinese population: a Mendelian randomization analysis.

International journal of obesity (2005) - 1 Nov 2016

Wang T, Ma X, Tang T, Jin L, Peng D, Zhang R, Chen M, Yan J, Wang S, Yan D, He Z, Jiang F, Cheng X, Bao Y, Liu Z, Hu C, Jia W

Abstract excerpt

BACKGROUND/OBJECTIVES: Clinical heterogeneity exists in overall obesity and obesity in terms of susceptibility to type 2 diabetes, but the relationship is vulnerable to be confounded by traditional risk factors in epidemiological studies. We aimed to characterize the impact of obesity in insulin secretion and sensitivity by using Mendelian randomization (MR) approach with genetic variants. SUBJECTS/METHODS: We...

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PMID: 27569682
DOI: 10.1038/ijo.2016.155

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