Article
Genetic Evidence of Causal Relation Between Intestinal Glucose Absorption and Early Postprandial Glucose Response: A Mendelian Randomization Study.
Diabetes - 1 Jun 2024
Peschard Simon, Raverdy Violeta, Bauvin Pierre, Goutchtat Rebecca, Touche Veronique, Derudas Bruno, Gheeraert Celine, Dubois-Chevalier Julie, Caiazzo Robert, Baud Gregory, Marciniak Camille, Verkindt Helene, Oukhouya Daoud Naima, Le Roux Carel W, Lefebvre Philippe, Staels Bart, Lestavel Sophie, Pattou François
Abstract excerpt
The postprandial glucose response is an independent risk factor for type 2 diabetes. Observationally, early glucose response after an oral glucose challenge has been linked to intestinal glucose absorption, largely influenced by the expression of sodium-glucose cotransporter 1 (SGLT1). This study uses Mendelian randomization (MR) to estimate the causal effect of intestinal SGLT1 expression on early glucose...
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