Article

Natural tolerance to transposition is associated with double-strand break repair and germ-cell differentiation

2021-04-30

Abstract excerpt

Transposable elements (TE) are mobile genetic parasites whose unregulated activity in the germline causes DNA damage and sterility. While the regulation of TE mobilization by hosts is studied extensively, little is known about mechanisms that could allow germline cells to persist in the face of genotoxic stress imposed by active transposition. Such tolerance mechanisms are predicted to be beneficial when new TEs i...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 158c4b3b-f556-5c54-85bb-9a3306506f48
DOI: 10.1101/2021.04.30.441852

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Natural tolerance to transposition is associated with double-strand break repair and germ-cell differentiationDOI 10.1101/2021.04.30.441852Read

Genetic variation in P-element dysgenic sterility is associated with double-strand break repair and alternative splicing of TE transcripts.Semantic proximity Read

Tolerance thresholds underlie responses to DNA damage during germline developmentSemantic proximity Read

QTL mapping of natural variation reveals that the developmental regulator <i>bruno</i> reduces tolerance to <i>P-</i> element transposition in the <i>Drosophila</i> female germlineSemantic proximity Read

Hybrid dysgenesis in <i>Drosophila simulans</i> associated with a rapid invasion of the <i>P</i> -elementSemantic proximity Read

Transposable elements, genome evolution and transgenerational epigenetic variation.Semantic proximity Read

The impact of <i>P</i> -Element-induced hybrid dysgenesis on the male germline in <i>Drosophila simulans</i>Semantic proximity Read

Transposable elements contribute substantially to naturally occurring genetic lethality in Drosophila melanogaster.Semantic proximity Read

piRNAs Are Associated with Diverse Transgenerational Effects on Gene and Transposon Expression in a Hybrid Dysgenic Syndrome of D. virilis.Semantic proximity Read

Hybrid Dysgenesis in Drosophila simulans Associated with a Rapid Invasion of the P-Element.Semantic proximity Read

Adaptation to transposable elements in Drosophila simulansSemantic proximity Read

p53 is required for female germline stem cell maintenance in <i>P</i> -element hybrid dysgenesisSemantic proximity Read

Epigenetic conflict on a degenerating Y chromosome increases mutational burden in Drosophila males.Semantic proximity Read