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Article

Genetic variation in P-element dysgenic sterility is associated with double-strand break repair and alternative splicing of TE transcripts.

PLoS genetics - 1 Dec 2022

Lama Jyoti, Srivastav Satyam, Tasnim Sadia, Hubbard Donald, Hadjipanteli Savana, Smith Brittny R, Macdonald Stuart J, Green Llewellyn, Kelleher Erin S

Abstract excerpt

The germline mobilization of transposable elements (TEs) by small RNA mediated silencing pathways is conserved across eukaryotes and critical for ensuring the integrity of gamete genomes. However, genomes are recurrently invaded by novel TEs through horizontal transfer. These invading TEs are not targeted by host small RNAs, and their unregulated activity can cause DNA damage in germline cells and ultimately lead...

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Identifiers

PMID: 36477699
DOI: 10.1371/journal.pgen.1010080
PMCID: PMC9762592

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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