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Article

p53 activity is selectively licensed in the Drosophila stem cell compartment

11 Mar 2014

Abstract excerpt

Oncogenic stress provokes tumor suppression by p53 but the extent to which this regulatory axis is conserved remains unknown. Using a biosensor to visualize p53 action, we find that Drosophila p53 is selectively active in gonadal stem cells after exposure to stressors that destabilize the genome. Similar p53 activity occurred in hyperplastic growths that were triggered either by the Ras(V12) oncoprotein or by...

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PMID: 24618896
DOI: 10.7554/elife.01530

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