Article
Myc plays an important role in Drosophila P-M hybrid dysgenesis to eliminate germline cells with genetic damage.
Communications biology - 22 Apr 2020
Ota Ryoma, Kobayashi Satoru
Abstract excerpt
Genetic damage in the germline induced by P-element mobilization causes a syndrome known as P-M hybrid dysgenesis (HD), which manifests as elevated mutation frequency and loss of germline cells. In this study, we found that Myc plays an important role in eliminating germline cells in the context of HD. P-element mobilization resulted in downregulation of Myc expression in the germline. Myc knockdown caused...
Topics
- Animals
- Animals, Genetically Modified
- Apoptosis
- DNA Damage
- DNA Transposable Elements
- DNA-Binding Proteins
- Drosophila Proteins
- Drosophila melanogaster
- Female
- Fertility
- Gene Expression Regulation, Developmental
- Genotype
- Germ Cells
- Germ-Line Mutation
- Male
- Mutation Rate
- Phenotype
- Transcription Factors