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Article

Gene-level association analysis of systemic sclerosis: A comparison of African-Americans and White populations.

PloS one - 1 Jan 2018

Gorlova Olga Y, Li Yafang, Gorlov Ivan, Ying Jun, Chen Wei V, Assassi Shervin, Reveille John D, Arnett Frank C, Zhou Xiaodong, Bossini-Castillo Lara, Lopez-Isac Elena, Acosta-Herrera Marialbert, Gregersen Peter K, Lee Annette T, Steen Virginia D, Fessler Barri J, Khanna Dinesh, Schiopu Elena, Silver Richard M, Molitor Jerry A, Furst Daniel E, Kafaja Suzanne, Simms Robert W, Lafyatis Robert A, Carreira Patricia, Simeon Carmen Pilar, Castellvi Ivan, Beltran Emma, Ortego Norberto, Amos Christopher I, Martin Javier, Mayes Maureen D

Abstract excerpt

Gene-level analysis of ImmunoChip or genome-wide association studies (GWAS) data has not been previously reported for systemic sclerosis (SSc, scleroderma). The objective of this study was to analyze genetic susceptibility loci in SSc at the gene level and to determine if the detected associations were shared in African-American and White populations, using data from ImmunoChip and GWAS genotyping studies. The...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 29293537
DOI: 10.1371/journal.pone.0189498
PMCID: PMC5749683

Genes

PINX1
EXOC2
SCT
SERBP1
STAT1
TNFAIP3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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