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Article

Simulating autosomal genotypes with realistic linkage disequilibrium and a spiked-in genetic effect.

BMC bioinformatics - 2 Jan 2018

Shi M, Umbach D M, Wise A S, Weinberg C R

Abstract excerpt

BACKGROUND: To evaluate statistical methods for genome-wide genetic analyses, one needs to be able to simulate realistic genotypes. We here describe a method, applicable to a broad range of association study designs, that can simulate autosome-wide single-nucleotide polymorphism data with realistic linkage disequilibrium and with spiked in, user-specified, single or multi-SNP causal effects. RESULTS: Our...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 29291710
DOI: 10.1186/s12859-017-2004-2
PMCID: PMC5749028

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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