Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

RAREsim: A simulation method for very rare genetic variants.

American journal of human genetics - 7 Apr 2022

Null Megan, Dupuis Josée, Sheinidashtegol Pezhman, Layer Ryan M, Gignoux Christopher R, Hendricks Audrey E

Abstract excerpt

Identification of rare-variant associations is crucial to full characterization of the genetic architecture of complex traits and diseases. Essential in this process is the evaluation of novel methods in simulated data that mirror the distribution of rare variants and haplotype structure in real data. Additionally, importing real-variant annotation enables in silico comparison of methods, such as rare-variant...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Computer Simulation
Share to Genetic Variation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Haplotypes

Share to Models, Genetic

Share to Multifactorial Inheritance

Share to Research Design

Source

Open in PubMed Open full text

Identifiers

PMID: 35298919
DOI: 10.1016/j.ajhg.2022.02.009
PMCID: PMC9069075

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

RAREsim: A simulation method for very rare genetic variants.PMID 35298919Read ↗

RAREsim: A simulation method for very rare genetic variantsSemantic proximity Read ↗

RAREsim2: Flexible simulation of rare variant genetic data using real haplotypesSemantic proximity Read ↗

RAREsim2: flexible simulation of rare variant genetic data using real haplotypes.Semantic proximity Read ↗

Methodology for the analysis of rare genetic variation in genome-wide association and re-sequencing studies of complex human traits.Semantic proximity Read ↗

SimRare: a program to generate and analyze sequence-based data for association studies of quantitative and qualitative traits.Semantic proximity Read ↗

SeqSIMLA: a sequence and phenotype simulation tool for complex disease studies.Semantic proximity Read ↗

Reproducible simulations of realistic samples for next-generation sequencing studies using Variant Simulation Tools.Semantic proximity Read ↗

Ravages: An R package for the simulation and analysis of rare variants in multicategory phenotypes.Semantic proximity Read ↗

Simulating realistic genomic data with rare variants.Semantic proximity Read ↗

GeneBreaker - Variant simulation to improve the diagnosis of Mendelian rare genetic diseasesSemantic proximity Read ↗

GeneBreaker: Variant simulation to improve the diagnosis of Mendelian rare genetic diseases.Semantic proximity Read ↗

Population genetic simulations of complex phenotypes with implications for rare variant association tests.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.