Article
Simulating association studies: a data-based resampling method for candidate regions or whole genome scans.
Bioinformatics (Oxford, England) - 1 Oct 2007
Wright Fred A, Huang Hanwen, Guan Xiaojun, Gamiel Kevin, Jeffries Clark, Barry William T, de Villena Fernando Pardo-Manuel, Sullivan Patrick F, Wilhelmsen Kirk C, Zou Fei
Abstract excerpt
MOTIVATION: Reductions in genotyping costs have heightened interest in performing whole genome association scans and in the fine mapping of candidate regions. Improvements in study design and analytic techniques will require the simulation of datasets with realistic patterns of linkage disequilibrium and allele frequencies for typed SNPs. METHODS: We describe a general approach to simulate genotyped datasets for...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.