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Article

Predicting signatures of "synthetic associations" and "natural associations" from empirical patterns of human genetic variation.

PLoS computational biology - 1 Jan 2012

Chang Diana, Keinan Alon

Abstract excerpt

Genome-wide association studies (GWAS) have in recent years discovered thousands of associated markers for hundreds of phenotypes. However, associated loci often only explain a relatively small fraction of heritability and the link between association and causality has yet to be uncovered for most loci. Rare causal variants have been suggested as one scenario that may partially explain these shortcomings....

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Identifiers

PMID: 22792059
DOI: 10.1371/journal.pcbi.1002600
PMCID: PMC3390358

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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