Article
Loss of maternal Trim28 causes male-predominant early embryonic lethality.
Genes & development - 1 Jan 2017
Sampath Kumar Abhishek, Seah Michelle K Y, Ling Ka Yi, Wang Yaju, Tan Joel H L, Nitsch Sandra, Lim Shu Ly, Lorthongpanich Chanchao, Wollmann Heike, Low Diana H P, Guccione Ernesto, Messerschmidt Daniel M
Abstract excerpt
Global DNA demethylation is a hallmark of embryonic epigenetic reprogramming. However, embryos engage noncanonical DNA methylation maintenance mechanisms to ensure inheritance of exceptional epigenetic germline features to the soma. Besides the paradigmatic genomic imprints, these exceptions remain ill-defined, and the mechanisms ensuring demethylation resistance in the light of global reprogramming remain poorly...
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