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Article

Genetic Variability of SRC Family Kinases and Its Association with Platelet Hyperreactivity and Clinical Outcomes: A Systematic Review.

Current pharmaceutical design - 1 Jan 2018

Milanowski Lukasz, Rasul Fazila, Gajda Sylwia Natalia, Eyileten Ceren, Siller-Matula Jolanta, Postula Marek

Abstract excerpt

BACKGROUND: Platelet hyperactivity has been implicated in many cardiovascular (CV) events such as ischemic stroke, myocardial infarction and CV death. Genetic variability of platelet receptors has been shown to impact Src family kinases (SFKs) activation and in turn influence platelet activation. SFKs are important signal transmitters in platelets, interacting with several receptors as GPIIB/IIIa, GPIb, PEAR 1,...

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Topics

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Share to SRC gene
Share to Genetic Variation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Platelet Activation

Share to Platelet Glycoprotein GPIIb-IIIa Complex

Share to Polymorphism, Genetic

Share to src-Family Kinases

Source

Identifiers

PMID: 29237371
DOI: 10.2174/1381612824666171213105002

Genes

PEAR1
SRC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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