Effects of the brain-derived neurotropic factor variant Val66Met on cortical structure in late childhood and early adolescence.

doi:10.1016/j.jpsychires.2017.12.008

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Article

Effects of the brain-derived neurotropic factor variant Val66Met on cortical structure in late childhood and early adolescence.

Journal of psychiatric research - 1 Mar 2018

de Araujo Celia Maria, Zugman Andre, Swardfager Walter, Belangero Sintia Iole Nogueira, Ota Vanessa Kiyomi, Spindola Leticia Maria, Hakonarson Hakon, Pellegrino Renata, Gadelha Ary, Salum Giovanni Abrahão, Pan Pedro Mario, de Moura Luciana Monteiro, Del Aquilla Marco, Picon Felipe Almeida, Amaro Edson, Sato João Ricardo, Brietzke Elisa, Grassi-Oliveira Rodrigo, Rohde Luis Augusto P, Miguel Euripedes Constantino, Bressan Rodrigo A, Jackowski Andrea Parolin

Abstract excerpt

BACKGROUND: The brain-derived neurotrophic factor (BDNF) Val66Met polymorphism (rs6265) has been associated with several neuropsychiatric disorders and regional structural brain changes in adults, but little is known about Val66Met's effect on brain morphology during typical or atypical neurodevelopment. Windows of vulnerability to psychopathology may be associated with the different alleles of the Val66Met...

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PMID: 29288952
DOI: 10.1016/j.jpsychires.2017.12.008

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