Article
Kernel machine methods for integrative analysis of genome-wide methylation and genotyping studies.
Genetic epidemiology - 1 Mar 2018
Zhao Ni, Zhan Xiang, Huang Yen-Tsung, Almli Lynn M, Smith Alicia, Epstein Michael P, Conneely Karen, Wu Michael C
Abstract excerpt
Many large GWAS consortia are expanding to simultaneously examine the joint role of DNA methylation in addition to genotype in the same subjects. However, integrating information from both data types is challenging. In this paper, we propose a composite kernel machine regression model to test the joint epigenetic and genetic effect. Our approach works at the gene level, which allows for a common unit of analysis...
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