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kTWAS: integrating kernel machine with transcriptome-wide association studies improves statistical power and reveals novel genes.

Briefings in bioinformatics - 20 Jul 2021

Cao Chen, Kwok Devin, Edie Shannon, Li Qing, Ding Bowei, Kossinna Pathum, Campbell Simone, Wu Jingjing, Greenberg Matthew, Long Quan

Abstract excerpt

The power of genotype-phenotype association mapping studies increases greatly when contributions from multiple variants in a focal region are meaningfully aggregated. Currently, there are two popular categories of variant aggregation methods. Transcriptome-wide association studies (TWAS) represent a set of emerging methods that select variants based on their effect on gene expressions, providing pretrained linear...

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PMID: 33200776
DOI: 10.1093/bib/bbaa270

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