Article
Association tests using kernel-based measures of multi-locus genotype similarity between individuals.
Genetic epidemiology - 1 Apr 2010
Mukhopadhyay Indranil, Feingold Eleanor, Weeks Daniel E, Thalamuthu Anbupalam
Abstract excerpt
In a genetic association study, it is often desirable to perform an overall test of whether any or all single-nucleotide polymorphisms (SNPs) in a gene are associated with a phenotype. Several such tests exist, but most of them are powerful only under very specific assumptions about the genetic effects of the individual SNPs. In addition, some of the existing tests assume that the direction of the effect of each...
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