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Article

Composite Kernel Association Test (CKAT) for SNP-set joint assessment of genotype and genotype-by-treatment interaction in Pharmacogenetics studies.

Bioinformatics (Oxford, England) - 1 May 2020

Zhang Hong, Zhao Ni, Mehrotra Devan V, Shen Judong

Abstract excerpt

MOTIVATION: It is of substantial interest to discover novel genetic markers that influence drug response in order to develop personalized treatment strategies that maximize therapeutic efficacy and safety. To help enable such discoveries, we focus on testing the association between the cumulative effect of multiple single nucleotide polymorphisms (SNPs) in a particular genomic region and a drug response of...

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PMID: 32101275
DOI: 10.1093/bioinformatics/btaa125

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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