Article
Kernel machine SNP-set testing under multiple candidate kernels.
Genetic epidemiology - 1 Apr 2013
Wu Michael C, Maity Arnab, Lee Seunggeun, Simmons Elizabeth M, Harmon Quaker E, Lin Xinyi, Engel Stephanie M, Molldrem Jeffrey J, Armistead Paul M
Abstract excerpt
Joint testing for the cumulative effect of multiple single-nucleotide polymorphisms grouped on the basis of prior biological knowledge has become a popular and powerful strategy for the analysis of large-scale genetic association studies. The kernel machine (KM)-testing framework is a useful approach that has been proposed for testing associations between multiple genetic variants and many different types of...
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