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Article

Generation of Transgenic Mice that Conditionally Overexpress Tenascin-C.

Frontiers in immunology - 1 Jan 2021

Yonebayashi Saori, Tajiri Kazuko, Hara Mari, Saito Hiromitsu, Suzuki Noboru, Sakai Satoshi, Kimura Taizo, Sato Akira, Sekimoto Akiyo, Fujita Satoshi, Okamoto Ryuji, Schwartz Robert J, Yoshida Toshimichi, Imanaka-Yoshida Kyoko

Abstract excerpt

Tenascin-C (TNC) is an extracellular matrix glycoprotein that is expressed during embryogenesis. It is not expressed in normal adults, but is up-regulated under pathological conditions. Although TNC knockout mice do not show a distinct phenotype, analyses of disease models using TNC knockout mice combined with in vitro experiments revealed the diverse functions of TNC. Since high TNC levels often predict a poor...

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Identifiers

PMID: 33763067
DOI: 10.3389/fimmu.2021.620541
PMCID: PMC7982461

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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