Article
Generation of Transgenic Mice that Conditionally Overexpress Tenascin-C.
Frontiers in immunology - 1 Jan 2021
Yonebayashi Saori, Tajiri Kazuko, Hara Mari, Saito Hiromitsu, Suzuki Noboru, Sakai Satoshi, Kimura Taizo, Sato Akira, Sekimoto Akiyo, Fujita Satoshi, Okamoto Ryuji, Schwartz Robert J, Yoshida Toshimichi, Imanaka-Yoshida Kyoko
Abstract excerpt
Tenascin-C (TNC) is an extracellular matrix glycoprotein that is expressed during embryogenesis. It is not expressed in normal adults, but is up-regulated under pathological conditions. Although TNC knockout mice do not show a distinct phenotype, analyses of disease models using TNC knockout mice combined with in vitro experiments revealed the diverse functions of TNC. Since high TNC levels often predict a poor...
Topics
- Animals
- Chromosome Walking
- Cytokines
- Gene Expression Regulation, Developmental
- Genome
- Homozygote
- Inflammation Mediators
- Integrases
- Mice
- Mice, Inbred C57BL
- Mice, Transgenic
- Myocardial Infarction
- Neurodegenerative Diseases