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Article

Computational Studies Show How the H463R Mutation Turns hKv1.5 into an Inactivation State.

The journal of physical chemistry. B - 18 Jan 2024

Rahman Ramisha A, Zaman Bushra, Khan Mohammad Radid, Islam Md Shariful, Rashid Md Harunur

Abstract excerpt

The KCNA5 gene provides the code for the α-subunit of the potassium channel Kv1.5. The genetic variant H463R in the Kv1.5 channel has been reported to cause a functional loss in atrial fibrillation (AF) patients. Understanding the mutations at a molecular level is key to developing improved therapeutics concerning cardiac hKv1.5 and hKv1.4 channels. Molecular dynamics and umbrella sampling free energy simulations...

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Identifiers

PMID: 38179652
DOI: 10.1021/acs.jpcb.3c05634

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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