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Article

A propofol binding site in the voltage sensor domain mediates inhibition of HCN1 channel activity.

Science advances - 3 Jan 2025

Burtscher Verena, Wang Lei, Cowgill John, Chen Zi-Wei, Edge Christopher, Smith Edward, Chang Yongchang, Delemotte Lucie, Evers Alex S, Chanda Baron

Abstract excerpt

Hyperpolarization-activated and cyclic nucleotide-gated (HCN) ion channels are members of the cyclic nucleotide-binding family and are crucial for regulating cellular automaticity in many excitable cells. HCN channel activation contributes to pain perception, and propofol, a widely used anesthetic, acts as an analgesic by inhibiting the voltage-dependent activity of HCN channels. However, the molecular...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 39752505
DOI: 10.1126/sciadv.adr7427
PMCID: PMC11698089

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