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An In Vivo Metastasis Model Using Genotype-Defined Tumor Organoids.

Methods in molecular biology (Clifton, N.J.) - 1 Jan 2024

Morita Atsuya, Nakayama Mizuho, Oshima Hiroko, Oshima Masanobu

Abstract excerpt

Recent cancer genome analyses have identified frequently mutated genes that are responsible for the development and malignant progression of cancers, including colorectal cancer (CRC). We previously constructed mouse models that carried major driver mutations of CRC, namely Apc, Kras, Tgfbr2, Trp53, and Fbxw7, in combinations. Comprehensive histological analyses of the models showed a link between mutation...

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PMID: 39147970
DOI: 10.1007/978-1-0716-4023-4_6

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