Article

TGFβ signaling in cancer-associated fibroblasts drives a hepatic gp130-dependent pro-metastatic inflammatory program in CMS4 colorectal cancer subtype

2024-06-29

Abstract excerpt

Current molecular classification of colorectal cancer (CRC), the Consensus Molecular Subtypes (CMS), has highlighted the biological heterogeneity of CRC and enables patient stratification based on the molecular subtype of their tumor. The CMS4 subtype shows the worst prognosis and is linked to the highest occurrence of hepatic metastasis but the underlying molecular mechanisms remain unclear. In this study, we sho...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 020d1bc8-43d8-5fed-8d7e-d04e8936d62d
DOI: 10.1101/2024.06.25.600311

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

TGFβ signaling in cancer-associated fibroblasts drives a hepatic gp130-dependent pro-metastatic inflammatory program in CMS4 colorectal cancer subtypeDOI 10.1101/2024.06.25.600311Read

The IL6/JAK/STAT3 pathway as a therapeutic target for histological subtypes of colorectal cancerSemantic proximity Read

COL10A1+ fibroblasts promote colorectal cancer metastasis and M2 macrophage polarization with pan-cancer relevanceSemantic proximity Read

Enrichment of Cancer-Associated Fibroblasts, Macrophages, and Up-Regulated TNF-α Signaling in the Tumor Microenvironment of CMS4 Colorectal Peritoneal Metastasis.Semantic proximity Read

Organ Specificity and Heterogeneity of Cancer-Associated Fibroblasts in Colorectal CancerSemantic proximity Read

Transforming Growth Factor-β Signaling Pathway in Colorectal Cancer and Its Tumor MicroenvironmentSemantic proximity Read

Single-cell and spatial analysis reveal interaction of FAP+ fibroblasts and SPP1+ macrophages in colorectal cancerSemantic proximity Read

Blockade of IL-6 inhibits tumor immune evasion and improves anti–PD-1 immunotherapySemantic proximity Read

The landscape of cancer-associated fibroblasts in colorectal cancer liver metastasesSemantic proximity Read

Phenotypic heterogeneity and plasticity in colorectal cancer metastasisSemantic proximity Read

Integrated analysis of single cell and bulk RNA sequencing identifies CTHRC1+INHBA+CAF as drivers of colorectal cancer progressionSemantic proximity Read

TGFβ and the Tumor Microenvironment in Colorectal CancerSemantic proximity Read

Cancer-Associated Stromal Fibroblast-Derived Transcriptomes Predict Poor Clinical Outcomes and Immunosuppression in Colon CancerSemantic proximity Read