Article
Genetic Variations in the 3'-untranslated Regions of Genes Involved in the Cell Cycle and Apoptosis Pathways Affect Bladder Cancer Risk.
Cancer genomics & proteomics - 1 Jan 2000
Zhang Qiang, Wang Wenying, Xu Weidong, Du` Mulong, Ma Gaoxiang, Liu Hanting, Chu Haiyan, Tong N A, Wang Meilin, Shao Jianfeng, Zhang Zhengdong, Yuan Lin, Qian Jing
Abstract excerpt
BACKGROUND: Key genes related to cell cycle and apoptosis pathways play critical roles in bladder cancer. Single nucleotide polymorphisms (SNPs) in the 3'-untranslated regions (3'-UTR) of genes may impact microRNA (miRNA)-messenger RNA (mRNA) binding capacity and alter gene expression to contribute to the susceptibility of cancers. However, an association of genetic variations in cell cycle and apoptosis pathways...
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