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Article

Functional variants of RPS6KB1 and PIK3R1 in the autophagy pathway genes and risk of bladder cancer.

Archives of toxicology - 1 Jan 2022

Ma Lan, Zhang Dongjian, Huang Zhengkai, Zheng Rui, Du Mulong, Lv Qiang, Qin Chao, Chu Haiyan, Yuan Lin, Zhang Zhengdong

Abstract excerpt

Autophagy plays a critical role in cancer, since it can either suppress tumorigenesis by inhibiting cancer cell survival, or facilitate tumorigenesis by promoting cancer cell proliferation and tumor growth. However, the role of genetic variants of autophagy-regulated key genes for bladder cancer risk remained unclear. Here, we aimed to explore the association of bladder cancer with genetic variants on genes...

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PMID: 34668023
DOI: 10.1007/s00204-021-03173-2

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