The potential of SLC6A4 gene methylation analysis for the diagnosis and treatment of major depression.

doi:10.1016/j.jpsychires.2014.02.002

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Article

The potential of SLC6A4 gene methylation analysis for the diagnosis and treatment of major depression.

Journal of psychiatric research - 1 Jun 2014

Okada Satoshi, Morinobu Shigeru, Fuchikami Manabu, Segawa Masahiro, Yokomaku Kana, Kataoka Tsutomu, Okamoto Yasumasa, Yamawaki Shigeto, Inoue Takeshi, Kusumi Ichiro, Koyama Tsukasa, Tsuchiyama Kounosuke, Terao Takeshi, Kokubo Yosuke, Mimura Masaru

Abstract excerpt

We examined the utility of DNA methylation profiles at the CpG island of SLC6A4 (DMS) as a diagnostic biomarker for major depression (MD). In addition, the relationship between DMS and the serotonin transporter gene-linked polymorphic region (5-HTTLPR) allele, the severity of symptoms, number of...

Topics

Adult
Antidepressive Agents
Case-Control Studies
CpG Islands
DNA Methylation
Depressive Disorder, Major
Female
Genotype
Humans
Male
Middle Aged
Pharmacogenetics
Psychiatric Status Rating Scales

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Serotonin Plasma Membrane Transport Proteins

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Identifiers

PMID: 24657235
DOI: 10.1016/j.jpsychires.2014.02.002

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-24657235-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.