Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Clinical Significance of the Wild Type p53-Induced Phosphatase 1 Expression in Invasive Breast Cancer.

Clinical breast cancer - 1 Aug 2018

Inoue Yuka, Yamashita Nami, Kitao Hiroyuki, Tanaka Kimihiro, Saeki Hiroshi, Oki Eiji, Oda Yoshinao, Tokunaga Eriko, Maehara Yoshihiko

Abstract excerpt

BACKGROUND: Wild type p53-induced phosphatase 1 (Wip1), encoded by the protein phosphatase magnesium dependent 1 delta (PPM1D), inhibits p53. PPM1D amplification has been reported in breast cancer. Breast cancer can sometimes develop without a tumor protein 53 (TP53) mutation. In these cases, the p53 pathway might be disrupted by alternative mechanisms, and Wip1 is reported to be a key molecule involved....

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Carcinoma, Ductal, Breast
Share to Cell Nucleus

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Comparative Genomic Hybridization

Share to Cyclin-Dependent Kinase Inhibitor p21

Share to DNA Copy Number Variations

Share to Neoplasm Staging

Share to Protein Phosphatase 2C

Share to Tumor Suppressor Protein p53

Source

Identifiers

PMID: 29275106
DOI: 10.1016/j.clbc.2017.11.008

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Clinical Significance of the Wild Type p53-Induced Phosphatase 1 Expression in Invasive Breast Cancer.PMID 29275106Read ↗

Wip1 phosphatase in breast cancer.Semantic proximity Read ↗

The Wip1 Phosphatase acts as a gatekeeper in the p53-Mdm2 autoregulatory loop.Semantic proximity Read ↗

Genetic variants and mutations of PPM1D control the response to DNA damage.Semantic proximity Read ↗

The role of PPM1D in cancer and advances in studies of its inhibitorsSemantic proximity Read ↗

PPM1D/Wip1 is amplified, overexpressed, and mutated in human non-Hodgkin's lymphomas.Semantic proximity Read ↗

Gain-of-function mutations of PPM1D/Wip1 impair the p53-dependent G1 checkpoint.Semantic proximity Read ↗

The Wip1 phosphatase and Mdm2: Cracking the "Wip" on p53 stabilitySemantic proximity Read ↗

PPM1D/Wip1 is amplified, overexpressed, and mutated in human Non-Hodgkin LymphomasSemantic proximity Read ↗

The type 2C phosphatase Wip1: An oncogenic regulator of tumor suppressor and DNA damage response pathwaysSemantic proximity Read ↗

Chemical Inhibition of Wild-Type p53-Induced Phosphatase 1 (WIP1/PPM1D) by GSK2830371 Potentiates the Sensitivity to MDM2 Inhibitors in a p53-Dependent Manner.Semantic proximity Read ↗

Regulation of the Wip1 phosphatase and its effects on the stress response Julie Lowe, Hyukjin Cha, Mi-Ok Lee, Sharlyn J. Mazur, Ettore Appella, Albert J. Fornace Jr.Semantic proximity Read ↗

WIP1 phosphatase as a potential therapeutic target in neuroblastoma.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.