Article
Perspectives on the use of an endogenous gene target in studies of mutational specificity.
Mutation research - 1 Jan 2000
Drobetsky E A, Grosovsky A J, Glickman B W
Abstract excerpt
Mutational spectra have become increasingly important tools in generating a molecular level understanding of mutagenesis in mammalian cells. The work in this field has primarily involved the use of shuttle vector systems although some work has also been reported using endogenous cellular genes as mutational targets. In this communication we discuss the relative utility of these two approaches. We specifically...
Topics
- Adenine Phosphoribosyltransferase
- Animals
- Cell Line
- DNA Repair
- Genetic Vectors
- Humans
- Mutagenicity Tests
- Mutation
- Transcription, Genetic
- Ultraviolet Rays