Article
Broad-ranging natural metabotype variation drives physiological plasticity in healthy control inbred rat strains.
Journal of proteome research - 1 Apr 2011
Pontoizeau Clément, Fearnside Jane F, Navratil Vincent, Domange Céline, Cazier Jean-Baptiste, Fernández-Santamaría Cristina, Kaisaki Pamela J, Emsley Lyndon, Toulhoat Pierre, Bihoreau Marie-Thérèse, Nicholson Jeremy K, Gauguier Dominique, Dumas Marc E
Abstract excerpt
Maintaining homeostasis in higher organisms involves a complex interplay of multiple ubiquitous and organ-specific molecular mechanisms that can be characterized using functional genomics technologies such as transcriptomics, proteomics, and metabonomics and dissected out through genetic investigations in healthy and diseased individuals. We characterized the genomic, metabolic, and physiological divergence of...
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