Article
The Drosophila hep pathway mediates Lrrk2-induced neurodegeneration.
Biochemistry and cell biology = Biochimie et biologie cellulaire - 1 Aug 2018
Yang Dejun, Thomas Joseph M, Li Tianxia, Lee Youngseok, Liu Zhaohui, Smith Wanli W
Abstract excerpt
Although the pathogenesis of Parkinson's disease (PD) remains unclear, mutations in leucine-rich repeat kinase 2 (Lrrk2) are among the major causes of familial PD. Most of these mutations disrupt Lrrk2 kinase and (or) GTPase domain function, resulting in neuronal degeneration. However, the signal pathways underlying Lrrk2-induced neuronal degeneration are not fully understood. There is an expanding body of...
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