Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Kinase signaling dysfunction in Parkinson's disease: a reverse genetic approach in Drosophila.

Journal of neurogenetics - 1 Jun 2012

Huang Yong, Shenoy Sushila, Lu Bingwei, Liu Wencheng, Li Chenjian

Abstract excerpt

Drosophila genetics is one of the most powerful tools in modern biology. For many years, the "forward genetic" approach using Drosophila has been extraordinarily successful in elucidating the molecular pathways of many physiological processes and behaviors. Recently, the "reverse genetic" approach in Drosophila is increasingly being developed as a major tool for research in biology, especially in the study of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Animals, Genetically Modified
Share to Disease Models, Animal

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Drosophila

Share to Leucine-Rich Repeat Serine-Threonine Protein Kinase-2

Share to Parkinson Disease

Share to Proteasome Endopeptidase Complex

Share to Protein Kinases

Share to Protein Serine-Threonine Kinases

Source

Identifiers

PMID: 22486164
DOI: 10.3109/01677063.2012.672499

Genes

PINK1
PTEN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Kinase signaling dysfunction in Parkinson's disease: a reverse genetic approach in Drosophila.PMID 22486164Read ↗

Mitochondrial dysfunction and Parkinson's disease genes: insights from Drosophila.Semantic proximity Read ↗

PINK1-Parkin signaling in Parkinson’s disease: Lessons from DrosophilaSemantic proximity Read ↗

Drosophila Models of Parkinson's Disease: Discovering Relevant Pathways and Novel Therapeutic StrategiesSemantic proximity Read ↗

The Importance of Drosophila melanogaster Research to UnCover Cellular Pathways Underlying Parkinson’s DiseaseSemantic proximity Read ↗

The roles of kinases in familial Parkinson's disease.Semantic proximity Read ↗

Modeling Parkinson’s Disease in Drosophila: What Have We Learned for Dominant Traits?Semantic proximity Read ↗

Genetic LRRK2 models of Parkinson's disease: Dissecting the pathogenic pathway and exploring clinical applications.Semantic proximity Read ↗

Historical Perspective: Models of Parkinson’s DiseaseSemantic proximity Read ↗

Mitochondrial dysfunction in Drosophila PINK1 mutants is complemented by parkinSemantic proximity Read ↗

Loss of LRRK2/PARK8 induces degeneration of dopaminergic neurons in DrosophilaSemantic proximity Read ↗

Dispensable role of Drosophila ortholog of LRRK2 kinase activity in survival of dopaminergic neuronsSemantic proximity Read ↗

A <i>Drosophila</i> model for <i>LRRK2</i> -linked parkinsonismSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.