Article
ULK1 and JNK are involved in mitophagy incurred by LRRK2 G2019S expression.
Protein & cell - 1 Sept 2013
Zhu Yuangang, Wang Chunyan, Yu Mei, Cui Jie, Liu Liang, Xu Zhiheng
Abstract excerpt
Mutations in LR RK2 (Leucine rich repeat kinase 2) are a major cause of Parkinson's disease (PD). We and others reported recently that expression of the pathogenic gainof-function mutant form of LRRK2, LRRK2 G2019S, induces mitochondrial fission in neurons through DLP1. Here we provide evidence that expression of LRRK2 G2019S stimulates mitochondria loss or mitophagy. We have characterized several LRRK2...
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