Article
Parkin negatively regulates JNK pathway in the dopaminergic neurons of Drosophila.
Proceedings of the National Academy of Sciences of the United States of America - 19 Jul 2005
Cha Guang-Ho, Kim Sunhong, Park Jeehye, Lee Eunji, Kim Myungjin, Lee Sung Bae, Kim Jin Man, Chung Jongkyeong, Cho Kyoung Sang
Abstract excerpt
Parkin, an E3 ubiquitin ligase, has been found to be responsible for autosomal recessive juvenile parkinsonism characterized primarily by selective loss of dopaminergic neurons with subsequent defects in movements. However, the molecular mechanisms underlying this neuron loss remain elusive. Here, we characterized Drosophila parkin loss-of-function mutants, which exhibit shrinkage of dopaminergic neurons with...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.