Article
Inhibitors of LRRK2 kinase attenuate neurodegeneration and Parkinson-like phenotypes in Caenorhabditis elegans and Drosophila Parkinson's disease models.
Human molecular genetics - 15 Oct 2011
Liu Zhaohui, Hamamichi Shusei, Lee Byoung Dae, Yang Dejun, Ray Arpita, Caldwell Guy A, Caldwell Kim A, Dawson Ted M, Smith Wanli W, Dawson Valina L
Abstract excerpt
Mutations in leucine-rich repeat kinase 2 (LRRK2) have been identified as a genetic cause of familial Parkinson's disease (PD) and have also been found in the more common sporadic form of PD, thus positioning LRRK2 as important in the pathogenesis of PD. Biochemical studies of the disease-causing mutants of LRRK2 implicates an enhancement of kinase activity as the basis of neuronal toxicity and thus possibly the...
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