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Article

Pathology and gene mutations of aldosterone-producing lesions.

Endocrine journal - 28 Dec 2023

Nishimoto Koshiro, Ogishima Tadashi, Sugiura Yuki, Suematsu Makoto, Mukai Kuniaki

Abstract excerpt

The human adrenal cortex secretes aldosterone and cortisol as major corticosteroids. For their production, CYP11B2 and CYP11B1 catalyze the last steps in the syntheses of aldosterone and cortisol, respectively. In our previous study, CYP11B2 was the first successfully purified from rat adrenals and human clinical samples and then was proved to be aldosterone synthase. We demonstrated the immunohistochemistry for...

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PMID: 37766569
DOI: 10.1507/endocrj.EJ22-0492

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