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Article

Identification of variants of CYP3A4 and characterization of their abilities to metabolize testosterone and chlorpyrifos.

The Journal of pharmacology and experimental therapeutics - 1 Dec 2001

Dai D, Tang J, Rose R, Hodgson E, Bienstock R J, Mohrenweiser H W, Goldstein J A

Abstract excerpt

CYP3A4 is the most abundant isoform of cytochrome P450 (CYP) in adult human liver. It metabolizes numerous clinically, physiologically, and toxicologically important compounds. The expression of CYP3A4 varies 40-fold in individual human livers, and metabolism of CYP3A4 substrates varies at least...

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PMID: 11714865

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-11714865-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

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