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Article

Dendrimer-mediated delivery of N-acetyl cysteine to microglia in a mouse model of Rett syndrome.

Journal of neuroinflammation - 19 Dec 2017

Nance Elizabeth, Kambhampati Siva P, Smith Elizabeth S, Zhang Zhi, Zhang Fan, Singh Sarabdeep, Johnston Michael V, Kannan Rangaramanujam M, Blue Mary E, Kannan Sujatha

Abstract excerpt

BACKGROUND: Rett syndrome (RTT) is a pervasive developmental disorder that is progressive and has no effective cure. Immune dysregulation, oxidative stress, and excess glutamate in the brain mediated by glial dysfunction have been implicated in the pathogenesis and worsening of symptoms of RTT. In this study, we investigated a new nanotherapeutic approach to target glia for attenuation of brain...

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Identifiers

PMID: 29258545
DOI: 10.1186/s12974-017-1004-5
PMCID: PMC5735803

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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