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Article

System xC- is a mediator of microglial function and its deletion slows symptoms in amyotrophic lateral sclerosis mice.

Brain : a journal of neurology - 1 Jan 2015

Mesci Pinar, Zaïdi Sakina, Lobsiger Christian S, Millecamps Stéphanie, Escartin Carole, Seilhean Danielle, Sato Hideyo, Mallat Michel, Boillée Séverine

Abstract excerpt

Amyotrophic lateral sclerosis is the most common adult-onset motor neuron disease and evidence from mice expressing amyotrophic lateral sclerosis-causing SOD1 mutations suggest that neurodegeneration is a non-cell autonomous process where microglial cells influence disease progression. However, microglial-derived neurotoxic factors still remain largely unidentified in amyotrophic lateral sclerosis. With...

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Identifiers

PMID: 25384799
DOI: 10.1093/brain/awu312
PMCID: PMC4441079

Genes

SOD1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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