Article
Dendrimer nanotherapy targeting of glial dysfunction improves inflammation and neurobehavioral phenotype in adult female Mecp2-heterozygous mouse model of Rett syndrome.
Journal of neurochemistry - 1 May 2024
Khoury Elizabeth Smith, Patel Ruchit V, O'Ferrall Caroline, Fowler Amanda, Sah Nirnath, Sharma Anjali, Gupta Siddharth, Scafidi Susanna, Kurtz Joshua S, Olmstead Sarah J, Kudchadkar Sapna R, Kannan Rangaramanujam M, Blue Mary E, Kannan Sujatha
Abstract excerpt
Rett syndrome is an X-linked neurodevelopmental disorder caused by mutation of Mecp2 gene and primarily affects females. Glial cell dysfunction has been implicated in in Rett syndrome (RTT) both in patients and in mouse models of this disorder and can affect synaptogenesis, glial metabolism and inflammation. Here we assessed whether treatment of adult (5-6 months old) symptomatic Mecp2-heterozygous female mice...
Topics
- Animals
- Rett Syndrome
- Female
- Methyl-CpG-Binding Protein 2
- Mice
- Neuroglia
- Disease Models, Animal
- Dendrimers
- Phenotype
- Mice, Inbred C57BL