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Article

CX3CR1 ablation ameliorates motor and respiratory dysfunctions and improves survival of a Rett syndrome mouse model.

Brain, behavior, and immunity - 1 Feb 2017

Horiuchi Makoto, Smith Lucas, Maezawa Izumi, Jin Lee-Way

Abstract excerpt

Rett syndrome (RTT) is a neurodevelopmental disorder caused by loss-of-function mutations in the gene encoding MeCP2, an epigenetic modulator that binds the methyl CpG dinucleotide in target genes to regulate transcription. Previously we and others reported a role of microglia in the pathophysiology of RTT. Because microglia in the Mecp2 knockout (Mecp2KO) mouse model of RTT over-produce neurotoxic mediators...

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Source

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Identifiers

PMID: 26883520
DOI: 10.1016/j.bbi.2016.02.014
PMCID: PMC5531048

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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