Dysregulated brain immunity and neurotrophin signaling in Rett syndrome and autism spectrum disorders.

Abstract excerpt

Rett syndrome is a neurodevelopmental disorder, which occurs in about 1:15,000 females and presents with neurologic and communication defects. It is transmitted as an X-linked dominant linked to mutations of the methyl-CpG-binding protein (MeCP2), a gene transcription suppressor, but its definitive pathogenesis is unknown thus hindering development of effective treatments. Almost half of children with Rett...

Topics

• Brain
• Child Development Disorders, Pervasive
• Corticotropin-Releasing Hormone
• Cytokines
• Female
• Humans
• Male
• Methyl-CpG-Binding Protein 2
• Mutation
• Nerve Growth Factors
• PubMed