Article
The amino-terminus of the hepatitis C virus (HCV) p7 viroporin and its cleavage from glycoprotein E2-p7 precursor determine specific infectivity and secretion levels of HCV particle types.
PLoS pathogens - 1 Dec 2017
Denolly Solène, Mialon Chloé, Bourlet Thomas, Amirache Fouzia, Penin François, Lindenbach Brett, Boson Bertrand, Cosset François-Loïc
Abstract excerpt
Viroporins are small transmembrane proteins with ion channel activities modulating properties of intracellular membranes that have diverse proviral functions. Hepatitis C virus (HCV) encodes a viroporin, p7, acting during assembly, envelopment and secretion of viral particles (VP). HCV p7 is released from the viral polyprotein through cleavage at E2-p7 and p7-NS2 junctions by signal peptidase, but also exists as...
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