Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Intramembrane processing by signal peptide peptidase regulates the membrane localization of hepatitis C virus core protein and viral propagation.

Journal of virology - 1 Sept 2008

Okamoto Kiyoko, Mori Yoshio, Komoda Yasumasa, Okamoto Toru, Okochi Masayasu, Takeda Masatoshi, Suzuki Tetsuro, Moriishi Kohji, Matsuura Yoshiharu

Abstract excerpt

Hepatitis C virus (HCV) core protein has shown to be localized in the detergent-resistant membrane (DRM), which is distinct from the classical raft fraction including caveolin, although the biological significance of the DRM localization of the core protein has not been determined. The HCV core protein is cleaved off from a precursor polyprotein at the lumen side of Ala(191) by signal peptidase and is then...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aspartic Acid Endopeptidases
Share to Clone Cells

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Fluorescent Antibody Technique, Direct

Share to Intracellular Membranes

Share to Kidney

Share to Protein Processing, Post-Translational

Share to Valine

Share to Viral Core Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 18562515
DOI: 10.1128/JVI.00306-08
PMCID: PMC2519675

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Intramembrane processing by signal peptide peptidase regulates the membrane localization of hepatitis C virus core protein and viral propagation.PMID 18562515Read ↗

The potential of signal peptide peptidase as a therapeutic target for hepatitis C.Semantic proximity Read ↗

Maturation of hepatitis C virus core protein by signal peptide peptidase is required for virus production.Semantic proximity Read ↗

Core protein cleavage by signal peptide peptidase is required for hepatitis C virus-like particle assembly.Semantic proximity Read ↗

Palmitoylation of hepatitis C virus core protein is important for virion production.Semantic proximity Read ↗

Internally located signal peptides direct hepatitis C virus polyprotein processing in the ER membrane.Semantic proximity Read ↗

The amino-terminus of the hepatitis C virus (HCV) p7 viroporin and its cleavage from glycoprotein E2-p7 precursor determine specific infectivity and secretion levels of HCV particle types.Semantic proximity Read ↗

Characterization of the cleavage of signal peptide at the C-terminus of hepatitis C virus core protein by signal peptide peptidase.Semantic proximity Read ↗

Hepatitis C Virus p7 is Critical for Capsid Assembly and EnvelopmentSemantic proximity Read ↗

Hepatitis C Virus P7—A Viroporin Crucial for Virus Assembly and an Emerging Target for Antiviral TherapySemantic proximity Read ↗

The Replacement of 10 Non-Conserved Residues in the Core Protein of JFH-1 Hepatitis C Virus Improves Its Assembly and Secretion.Semantic proximity Read ↗

Production and pathogenicity of hepatitis C virus core gene productsSemantic proximity Read ↗

Signal Peptide Peptidase Cleavage of GB Virus B Core Protein Is Required for Productive Infection in VivoSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.