Article
Genetic Diversity Underlying the Envelope Glycoproteins of Hepatitis C Virus: Structural and Functional Consequences and the Implications for Vaccine Design.
Viruses - 17 Jul 2015
Tarr Alexander W, Khera Tanvi, Hueging Kathrin, Sheldon Julie, Steinmann Eike, Pietschmann Thomas, Brown Richard J P
Abstract excerpt
In the 26 years since the discovery of Hepatitis C virus (HCV) a major global research effort has illuminated many aspects of the viral life cycle, facilitating the development of targeted antivirals. Recently, effective direct-acting antiviral (DAA) regimens with >90% cure rates have become available for treatment of chronic HCV infection in developed nations, representing a significant advance towards global...
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