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Article

Unexpected Structural Features of the Hepatitis C Virus Envelope Protein 2 Ectodomain

3 Jul 2014

Abstract excerpt

Hepatitis C virus (HCV), a member of the family Flaviviridae, is a leading cause of chronic liver disease and cancer. Recent advances in HCV therapeutics have resulted in improved cure rates, but an HCV vaccine is not available and is urgently needed to control the global pandemic. Vaccine development has been hampered by the lack of high-resolution structural information for the two HCV envelope glycoproteins,...

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PMID: 24991010
DOI: 10.1128/jvi.00874-14

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